A new and more efficient way of injecting insulin




A new and more efficient way of injecting insulin

In addition to the inconvenience of daily injections of insulin, diabetics of the first type are constantly at risk of even more harm to your health, if necessary dose of injection was chosen incorrectly. In the future, it was possible to get around these two problems, U.S. researchers decided to develop a new method. Its essence is based on a network of specific nanoparticles are injected into the human body. These particles, with increasing sugar level, begin to release insulin available to them and thus can keep a normal blood sugar over one week, without requiring additional injections.

Themselves nanoparticles consist of a core, which is performing the role of insulin, dextran (used to thin the blood), and the enzyme glucose oxidase. When the glucose, enzymes convert it to gluconic acid portion, which in turn cleaves dextran shell and thereby releases the required dose of insulin. Gluconic acid and dextran being biocompatible simply dissolve in the body, and the resulting insulin helps keep blood glucose under control.

Further, since these nanoparticles used positively and negatively charged biocompatible membrane, they are attracted to each other, thus forming a “nanoset.” A positively charged shell consists of chitosan material is usually produced from crustacean shells. This material is often used in so-called self-healing automotive paint. Role of the negatively charged membrane in this case operate alginates encountered in marine algae.

“This technology is literally injected inside the body creates its closed system, which begins to mimic the pancreas healthy person,” – says Dr. Zhen Gu, an assistant professor from North Carolina State University and the University of North Carolina at Chapel Hill.

“The new method could one day help and improve the health and quality of life of diabetic patients.”

The technology, developed jointly by researchers from North Carolina State, North Carolina State University, MIT (Massachusetts Institute of Technology) and the Children’s Hospital in Boston, as part of the laboratory tests on animals has shown efficacy in normalizing blood sugar levels within a week. Currently, scientists are discussing the possibility of transition to clinical trials have directly with the people.
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