Bioengineers have learned to seek out and kill the bacteria pathogens




Escherichia coli

A group of researchers from Singapore has developed the technology of programming bacteria to search for and destruction of pathogens . In an article published in the journal ACS Synthetic Biology, describes how bioengineering technique that has been successfully tested on mice, could be applied to humans.

Many researchers in the field of health care dream of finding a universal remedy for all kinds of diseases – an ideal vaccine or medication that would be able to destroy the invasive pathogens, without affecting healthy tissue. It seems that Singaporean scientists closer to that dream – they have learned to program one type of bacteria to kill others.

In the laboratory using a specially written program of biological scientists ordered the bacteria Escherichia coli to find and destroy Pseudomonas aeruginosa – rod-shaped bacterium that could cause pneumonia and other diseases dangerous to humans. At the beginning of the experiment, researchers implanted a single bacterium E. coli gene that caused her to develop peptide microcin S, known as the “killer bacteria”. Then they added the genes responsible for the production of nuclease enzyme that breaks down the biofilm produced by micro-organisms to block anti-bacterial agents.

As a result, bacteria-killer detects the target, produce microcin S, then immediately destroyed the enemy. Testing feces of mice before and after application of the program showed that the number of P. aeruginosa body in rodents decreased, and the amount of beneficial intestinal bacteria are not changed.

The absence of any other symptoms or side effects on safety and indicates the effectiveness of the bioengineering techniques. Inspired by the researchers plan to adapt the technology for the treatment of people from a variety of bacterial infections. Currently, scientists are trained to “mercenaries” effectively destroy the protective shell biofilm.

Earlier, the U.S. bioengineers have grown beating heart of the reprogrammed cells .
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Tags: Bioengineering , Biology , Cell , Medical .

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