Chemists have created needle pills




The researchers presented a new pill that can replace injection. According to scientists, this form provides a more efficient delivery of drugs into the body than simple pills. But there is one feature – the surface is covered with tiny needles pills.

Researchers at the Massachusetts Institute of Technology and Massachusetts General Hospital (MGH) have created an innovative capsule coated with tiny needles through which the drug directly into the gastric mucosa, the British newspaper Daily Mail.

Animal studies – as guinea pigs were selected – showed that the capsule delivers insulin more effectively than the injection under the skin. Thus scientists were not observed any harmful side effects after passage of the capsules through the digestive tract.

Researchers hoped that the capsule will not work effectively with only insulin but also other biopharmaceuticals, such as antibodies that are used to treat cancer and autoimmune disorders of the body, such as arthritis and Crohn’s disease. To biopreparations also include vaccines, recombinant DNA and RNA.

The large size of biological resources affected their absorption. Acids and enzymes in the gastrointestinal tract will destroy them before they have a chance to soak in the body, – explained the lead author, chemist Carl Shёllhammer.

Effective delivery of drugs in the body is also possible with the help of micro-and nanoparticles, but this method is associated with high costs. production of these particles is expensive, and every single tool requires the development of a new version of the dosage form.

Prototype acrylic capsule (2 cm long and 1 cm in diameter) consists of a reservoir for the drug and hollow microneedles coated stainless steel of length about 5 mm.

Previous studies have shown that accidental ingestion pills with short needles carries no risk to health. The patients feel no pain from receiving a pill, as in the gastrointestinal tract no pain receptors.

Moving the capsule around the digestive tract took a little more than a week. The researchers found no traces of tissue damage, suggesting that the potential safety of such a dosage form.

According to scientists, the same method can be administered the vaccine. Researchers plan modified pill so that when reducing the wall of the alimentary canal occurred slowly squeezing the drug out of the capsule. They also develop needles of biodegradable polymers and sugars, which could dissolve in the body after drug release.

In the world there are so many different drugs, and inhumane use threatens public health .


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