Insulin capsules could replace daily injections




Scientists from the Indian National Institute for Research in the field of pharmaceuticals, it seems, have discovered a new way to deliver insulin into the bloodstream. Maybe in the near time, people with diabetes will be able to finally give the order of the annoying daily injections of insulin and replace this unpleasant process to receive conventional tablets, which contain the much needed hormone.

Creating insulin tablets until now hindered by two factors: the digestive enzymes almost completely destroyed the insulin before the body can take it, as well as very poor insulin enters the bloodstream from the intestine.

To protect insulin from enzyme hazardous hormone, researchers packed it into a “liposome” – artificially created tiny hollow sphere envelope which consists of lipids (in our case – a fat molecules). After that liposomes are covered with additional protective layers of polieliktrolitov and only then they can not swallow.

Scientists also added to each sphere folic acid, as previous studies have shown that this acid allows liposomes successfully penetrate the intestinal wall into the bloodstream.

Of course, as in many other scientific experiments, this method of delivery of insulin into the body first tested on laboratory rats. After rats were orally given the insulin-containing formulation, the blood glucose decreased by about rodent to the same level if they were injected dose of insulin. Moreover, the effect lasted longer tablets than from the injections.

Indian scientists research results were published in the journal Biomacromolecules and has already made a lot of noise in the scientific community. Researchers from the United States are also developing an alternative to daily injections of insulin, but they are exploring the use of pulsed ultrasound to deliver the hormone into the body.

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Tags: Health , India , Medicine .


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