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Like pacemakers replaced by genetic engineering scientists




Taiwanese and American scientists propose a way found to replace a biological variant. Traditional pacemaker in cardiac patients Genetic modification cardiomyocytes are converted into pacemaker cells.

The method is by scientists published in the authoritative scientific journal Science. Normally, patients with certain types of heart failure, an implanted device that uses electrical impulses to the heart turn to keep pumping. The Taiwanese and American scientists say that they can replace a biological variant through reprogramming conventional cardiomyocytes. These traditional pacemakers

They have developed a method that with the aid of genetic modification ensures that cardiomyocytes, or heart muscle cells, are converted into pacemaker cells. These are nerve cells that are able to be pumped by stimulation with electric pulses. The rest of the heart Moreover, also a healthy heart pacemaker cells of this type, which are in communication with the brains and the unconscious part of the nervous system.

The genetic modification of the heart muscle cells works by injection with a modified virus that is able to infect the cells. Because the scientists transport packets with genetic material in the viruses, and this is then incorporated into the genome of the cell of the cell behavior changes. As a result, it will be reprogrammed from cardiac cell to nerve cell. There was only one gene is “turned on” to make changes. Cardiomyocytes behavior

In a study with pigs, which in terms of organ function are very similar to humans, showed that the reprogramming of cells may cause a stopped heart was pumping. Autonomous again However, it will take some time before the method is useful for people. The study period was two weeks, with relatively short and it is not yet clear whether the reprogramming of human cells will also be successful. In addition, scientists will probably first have to do in order to show that their method is safe more research.


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