Nanoparticles of gold as a key to new kinds of vaccination




Nanoparticles of gold as a key to new kinds of vaccination


Usually implies a vaccination administration of a weakened or killed microorganisms (viruses) for creating strong immunity to possible future infections. However, writes portal Institute of Physics, a group of American scientists have developed a new method of vaccination, which involves the use of nanoparticles of gold , with the ability to simulate the behavior of the virus and is intended for delivery to the cells of the immune system of special types of proteins.

In a recent study, the researchers decided to test this method on respiratory syncytial virus (RSV) – the virus that causes respiratory tract infections in infants and children, and from which in nature, unfortunately, there is no vaccine. The difficulty is that the F protein of the virus virion allows it to penetrate into the cells and causes their plasmatic membrane fusion with neighboring cells. The natural immune system itself can determine the protein, but researchers still have not found the right method of vaccination against this infection. The new method is, in turn, allows the immune system to remember a situation in which there is an infection and promptly respond to it.

In this study, scientists have created a kind of golden nanotubes coated with a membrane protein F of the virus RSV. The essence of the work of scientists was to determine the ability of the gold nanotubes delivery F protein to the cells of the immune system when using blood samples adult. The results showed that the gold particles were not only able to simulate the behavior of the virus and stimulate the immune system to respond quickly, but were harmless to healthy cells.

“The vaccine against RSV, which in turn is a fairly common cause of viral pneumonia in children, simply vital. This study shows that we have developed a method of delivery of the protein F of the virus RSV, in which the protein is transported to the cells of the immune system to specific nanoparticles, which simulate the behavior of the virus. Moreover, by themselves, these particles are not pathogenic, “- says Professor James Crowe, chief scientist of the study.

Professor Crowe also believes that the use of these gold nanoparticles is not limited to the fight against RSV. Particles can be used to develop vaccines against almost any virus, bacterial and fungal infections.
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