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Pharmacists have created a strong painkiller addiction without
American pharmacists have created a new type of opioid, which relieves pain with much less risk of side effects such as dependency and suppression of consciousness . The drug has been successfully tested on humans.
Patients who experienced the analgesic properties of a new experimental drug, found it “boring,” writes resource Technology Review citing Chief Medical biopharmaceutical company Nektar Therapeutics Rob Miedwie.
The drug does not cause joy or euphoria, – he says, noting that human trials showed an increase in pain threshold.
Opioid (narcotic) analgesics, which include morphine, to this day is the best way to relieve severe pain. However, with a strong pain relief, they increase the level of dopamine (a feeling of pleasure) in the brain, which leads to chronic addiction. According to the Department of Health and Human Services, nearly two million Americans “sitting” on opioids, and in the year recorded about 14 000 cases of drug overdose of these drugs.
Researchers are developing a more sparing years painkillers, trying to separate the useful analgesic properties of side effects.
California-based Nektar Therapeutics used the following approach: a derivative of morphine was added to the side chain, which has changed the behavior of molecules in the body. Incoming speed component in the brain has slowed making it impassable through the blood-brain barrier (between blood and cerebrospinal fluid) which protects the central nervous system from alien invasion. This reduces the risk of drug abuse, the researchers said.
Opioid drugs, such as heroin (a derivative of morphine), very quickly reach the brain and cause euphoria. A new type of opioid enters the brain is too slow, do not thereby provoking the abuse.
Nektar Therapeutics has completed testing of the drug’s safety in humans. The researchers believe that the new synthetic compound has the potential to become an effective and safe analgesic.
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Tags: Nektar Therapeutics , Medicine , Medicine .
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